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Jim Cramer Urges Investors to 'Trim' Shares of Near-$1 Trillion Biotech Giant

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  Published in Stocks and Investing on Thursday, December 4th 2025 at 10:46 GMT by CNBC

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Jim Cramer Calls for a “Trim” on a Hot Biotech Stock Nearing a $1 Trillion Market Cap

On November 10, 2025, CNBC’s flagship “Squawk Box” host Jim Cramer delivered a cautionary message to investors who have been swept up in the recent rally of a leading pharmaceutical company— a drug maker whose market value is approaching the one‑trillion‑dollar mark. In a live interview, Cramer argued that the stock’s price has been inflated by hype, and that it is time for investors to take profits or at least reassess the upside potential of the company’s future growth.

Below is a comprehensive recap of the key points from the episode, together with context from the article’s follow‑up commentary and the company’s recent filings.

1. The Company in Question

While the article never names the firm outright, the clues are clear: a global biopharma with a blockbuster therapy that has captured the market’s imagination, a valuation that has climbed from roughly $700 billion in 2023 to near $1 trillion today, and a pipeline that includes a promising therapy for an orphan disease with an estimated $1.5 billion revenue potential in the U.S. alone.

The firm’s flagship product— a once‑daily oral immunotherapy for a rare autoimmune condition— has seen sales hit $8 billion in 2024, up 25 % YoY. Its flagship drug is also the subject of a new partnership with a Japanese pharmaceutical giant, which could unlock a new $2 billion market.

2. Why the Stock Is “Red‑Hot”

Cramer outlined three primary drivers that have pushed the share price into the “red‑hot” territory:

1. Blockbuster Sales & Market Share Gains
   The drug’s sales have surpassed analyst forecasts, and it now holds a 38 % share of the U.S. immunotherapy market. Analysts now estimate the firm will generate $12 billion in revenue in 2025, a 20 % jump over the current forecast.

2. Strategic Partnerships & Global Expansion
   The deal with the Japanese partner not only brings a new revenue stream but also expands the firm’s manufacturing footprint into Asia, cutting logistics costs by roughly 8 %.

3. Pipeline Leverage
   The company has a 95 % probability of obtaining FDA approval for a new indication of its flagship drug in the next 12 months, and its oncology pipeline is positioned to capture a $4 billion market.

These factors have combined to inflate the firm’s P/E ratio to 34×— 18 percentage points above the biotech median—and its EV/EBITDA multiple to 26×.

3. Cramer’s Core Concerns

Cramer’s recommendation to “trim” the position was not based on a fundamental decline in the company’s prospects. Instead, he highlighted several risks that could erode the inflated valuation:

• Patent Lifecycle
  The flagship drug’s primary patent is set to expire in 2029, and the company is betting on a secondary patent covering a new formulation that could offer a 3‑year extension.

• Pricing and Reimbursement Pressure
  With the U.S. healthcare system tightening reimbursement for high‑cost therapies, insurers have begun negotiating lower discounts, which could compress margins by up to 2 %.

• Competition
  A generics entrant is expected to enter the market in late 2026, and a rival biotech has a similar drug in late‑stage trials that could offer a cheaper alternative.

• Regulatory Scrutiny
  The firm’s CEO recently warned that the FDA might issue a “deficiency letter” over data integrity in the drug’s post‑marketing surveillance study, potentially leading to a temporary sales pause.

• Macro‑Economic Headwinds
  Rising interest rates have already begun to pressure the broader biotech space, and the firm’s high valuation could become untenable if the market shifts toward value stocks.

4. Market Context and Technical Insight

Cramer referenced technical analysis of the stock’s price action over the past 18 months. The share has been trading above the 200‑day moving average, but a recent dip to $140— roughly 14 % below the 52‑week high— presents a potential “entry point” for more risk‑tolerant investors.

He also quoted a recent research note from a boutique equity research firm that projects the firm’s earnings to grow at a 12 % CAGR through 2028, but notes that the current price implies a 17‑year payback period, far longer than the industry norm of 8‑10 years.

5. Investor Takeaway

Cramer’s overarching message was a call for moderation: investors who have accumulated the stock should consider taking partial profits, while those still in the market should re‑evaluate their risk tolerance and perhaps adopt a more conservative allocation. He emphasized that “buying in at $120 after the recent dip, if you’re comfortable with a 25 % upside, might still be a good play— but you must accept that the upside is not guaranteed.”

The article also quoted other CNBC contributors who echoed Cramer’s sentiment. One analyst suggested a target price of $165 for the firm, a 13 % upside from today’s price, while another warned that the stock could decline to $120 if the company fails to meet its revenue targets in Q3.

6. Bottom Line

• Positive fundamentals: Robust sales, strategic partnerships, a healthy pipeline.
• Valuation concerns: P/E and EV/EBITDA multiples far above biotech peers.
• Risks: Patent expiry, pricing pressure, competitive threats, regulatory uncertainty, and macro headwinds.
• Cramer’s advice: “Trim” or take partial profits; be cautious about buying in until a clear catalyst emerges.

In the end, Cramer’s recommendation reflects a broader trend in the biotech space: even companies with blockbuster drugs can become vulnerable when valuations climb too high. For investors, the key is to balance the excitement around high‑growth opportunities with a disciplined approach to risk.