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Alnylam Reports Strong Q4 and Full-Year 2025

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  Published in Stocks and Investing on Thursday, February 12th 2026 at 19:19 GMT by WTOP News
      Locales: Massachusetts, New York, California, UNITED STATES

BOSTON, MA - February 13th, 2026 - Alnylam Pharmaceuticals (NASDAQ: ALNY) today reported a strong fourth quarter and full-year 2025 performance, solidifying its position as a leader in the rapidly evolving field of RNA interference (RNAi) therapeutics. The company's earnings snapshot, released this morning, revealed significant revenue growth, promising clinical trial advancements, and reaffirmed guidance, painting a positive outlook for the future.

Alnylam, a pioneer in RNAi technology, has consistently demonstrated its ability to translate cutting-edge science into impactful therapies for patients with rare genetic diseases. RNAi works by silencing specific genes, offering a fundamentally new approach to treating diseases at their source. This mechanism holds immense potential for addressing previously untreatable conditions, and Alnylam is at the forefront of realizing that potential.

The Q4 2025 results showcased substantial revenue increases, primarily driven by the continued uptake of its commercially available drugs, ONPATTRO and GIVLAARI. ONPATTRO, approved for hereditary transthyretin-mediated (hATTR) amyloidosis, remains a cornerstone of Alnylam's portfolio, delivering consistent performance and expanding its reach to more patients worldwide. GIVLAARI, indicated for acute hepatic porphyria (AHP), has also seen strong adoption, providing a life-changing treatment option for individuals suffering from this debilitating condition. The company's success isn't solely attributable to initial market penetration; expansions in patient access programs and increased awareness among healthcare professionals have also played critical roles.

Beyond commercial success, Alnylam's pipeline is brimming with potential. The earnings report highlighted encouraging data from several ongoing clinical trials. Notably, advancements in therapies targeting rare liver diseases and neurological disorders offered compelling preclinical and early clinical findings. While details regarding specific trial outcomes were reserved for the full earnings release, analysts anticipate substantial updates in the coming months, potentially showcasing breakthrough data that could redefine treatment paradigms for these diseases. These pipeline advancements are not merely incremental improvements; they represent a paradigm shift towards precision medicine and genetically targeted therapies.

The company's commitment to research and development remains unwavering. Alnylam is investing heavily in refining its RNAi delivery technologies, ensuring that therapeutic agents reach the intended tissues efficiently and safely. This focus on delivery is crucial, as it addresses one of the major challenges in RNAi drug development. The company is exploring innovative approaches, including lipid nanoparticles (LNPs) and other targeted delivery systems, to maximize the efficacy and minimize potential side effects of its therapies.

Investor reaction to the earnings report was positive, with shares experiencing a moderate increase in after-hours trading. This indicates investor confidence in Alnylam's current performance and, more importantly, its future prospects. Analysts covering the biotechnology sector noted the strength of Alnylam's existing franchises and the significant potential of its pipeline to drive continued growth. Several analysts revised their price targets upward, reflecting their optimistic outlook on the company.

During the earnings call, Alnylam's leadership team reaffirmed their full-year 2027 revenue and expense guidance, a testament to their confidence in the company's long-term strategy. This reaffirmation signals stability and predictability, reassuring investors that Alnylam is well-positioned to navigate the dynamic biotechnology landscape. Management emphasized a commitment to responsible growth, prioritizing both innovation and financial discipline.

Looking ahead, Alnylam plans to prioritize expanding access to its existing therapies, particularly in underserved populations. The company is actively collaborating with healthcare providers and patient advocacy groups to improve diagnosis rates and ensure that patients who could benefit from its treatments have timely access. Furthermore, Alnylam is strategically expanding its global footprint, bringing its innovative therapies to patients around the world. The company's dedication to addressing unmet medical needs across a broad range of genetic diseases remains the core of its mission.